Department of Chemical Engineering and Materials Science, Facalty of Sceince and Engineering, Doshisha University
Analytical Chemistry (Separation and Detection) Laboratory

Research Subjects

Research subjects and their main publications (chronological order)

(1) Flow analysis of biological constituents by use of chemiluminescence reaction (1982-)

  • Chemiluminescence Analysis of Biological Constituents Using Metal-Complex Catalysts. A Review: Tadashi Hara and Kazuhiko Tsukagoshi, Analytical Sciences, 6, 797-806 (1990).

(2) Molecular recognition of saccharides using phenylboronic acid derivatives (1990-)

  • Specific Complexation with Mono- and Disaccharides That Can Be Detected by Circular Dichroism: Kazuhiko Tsukagoshi and Seiji Shinkai, The Journal of Organic Chemistry, 56, 4089-4091 (1991).
  • Molecular Recognition of Mono- and Di-saccharides by Phenylboronic Acids in Solvent Extraction and as a Monolayer: Seiji Shinkai, Kazuhiko Tsukagoshi, Yuichi Ishikawa, and Toyoki Kunitake, Journal of the Chemical Society, Chemical Communications, 1991, 1039-1041.

(3) Surface imprinting polymerization and its application (1991-)

  • Metal Ion-Selective Adsorbent Prepared by Surface-Imprinting Polymerization: Kazuhiko Tsukagoshi, Kai Yu Yu, Mizuo Maeda, and Makoto Takagi, Bulletin of the Chemical Society of Japan, 66, 114-120 (1993).
  • Surface Imprinting. Characterization of a Latex Resin and the Original of the Imprinting Effect: Kazuhiko Tsukagoshi, Kai Yu Yu, Mizuo Maeda, Makoto Takagi, and Tohru Miyajima, Bulletin of the Chemical Society of Japan, 68, 3095-3103 (1995).

(4) Development of capillary electrophoresis-chemiluminescence detection system (1995-)

  • Separation and Determination of Phenolic Compounds by Capillary Electrophoresis with Chemiluninescence Detection; Kazuhiko Tsukagoshi, Takahide Kameda, Masayo Yamamoto, and Riichro Nakajima, Journal of Chromatography. A, 978, 213-220 (2002).
  • Batch-Type Chemiluminescence Detection Cell for Sensitization and Simplification of Capillary Electrophoresis: Kazuhiko Tsukagoshi, Takeshi Nakamura, and Riichiro Nakajima, Analytical Chemistry, 74, 4109-4116 (2002).
  • Microchip Capillary Electrophoresis Using On-Line Chemiluminescence Detection: Masahiko Hashimoto, Kazuhiko Tsukagoshi, Riichiro Nakajima, Kazuo Kondo, Akihiro Arai, Journal of Chromatography A,867, 271-279 (2000).
  • Direct Detection of Biomolecules in a Capillary Electrophoresis-Chemiluminescence Detection System: Kazuhiko Tsukagoshi, Koji Nakahama, and Riichiro Nakajima, Analytical Chemistry, 76, 4410-4415 (2004).
  • Development of a Micro-Total Analysis System Incorporating Chemiluminescence Detection and Application to Detection of Cancer Markers: Kazuhiko Tsukagoshi, Naoya Jinno, Riichiro Nakajima, Analytical Chemistry, 77, 1684-1688 (2005).
  • Chemiluminescence Detection for Capillary Electrophoresis and Liquid Chromatography. A Review; Kazuhiko Tsukagoshi, The Science and Engineering Review of Doshisha University, 45, 165-186 (2005).

(5) Development of chromatography using an open-tubular capillary tube (1998-)

  • Preparation of an Iminodiacetic Acid-Modified Capillary and Its performance in Capillary Liquid Chromatography and Immobilized Metal Chelate Affinity Capillary Electrophoresis: Kazuhiko Tsukagoshi, Yasushi Shimadzu, Tatsuhiko Yamane, and Riichiro Najima, Journal of Chromatography A, 1040, 151-154 (2004).
  • Selective Detection of Human Serum Albumin Using a Fused-Silica Capillary Modified with Anti-Human Serum Albumin: Kazuhiko Tsukagoshi, Hirofumi Indou, Kaori Sawanoi, Takako Oguni, and Riichiro Nakajima, Bulletin of the Chemical Society of Japan, 77, 1353-1357 (2004).

(6) Micro-channel chemiluminescence analysis (MCCLA) (2005-)

  • Micro-Channel Chemiluminescence Analysis Using Peroxyoxalate Reaction that Works through Liquid–liquid Interface Collapse under Laminar Flow Conditions: Kazuhiko Tsukagoshi, Yoshiyuki Hattori, Teruki Hayashi, Riichiro Nakajima, Kenichi Yamashita, and Hideaki Maeda, Analytical Sciences, 24, 1393-1398 (2008).
  • Metal Ion Analysis Using Microchip CE with Chemiluminescence Detection Dased on 1,10-Phenanthroline-Hydrogen Peroxide Reaction: Takahiro Nogami, Masahiko Hashimoto, and Kazuhiko Tsukagoshi, Journal of Separation Science, 32, 408-412 (2009).

(7) Clarification of phase separation multiphase flow and its functional appearance (2009-)

  • Capillary Chromatography Based on Tube Radial Distribution of Aqueous-Organic Mixture Carrier Solvents: Naoya Jinno, Minoru Itano, Masahiko Hashimoto, and Kazuhiko Tsukagoshi, Talanta, 79, 1348-1353 (2009).
  • Fluorescence Observation Supporting Capillary Chromatography Based on Tube Radial Distribution of Carrier Solvents under Laminar Flow Conditions: Naoya Jinno, Mari Murakami, Kiyoshi Mizohata, Masahiko Hashimoto, and Kazuhiko Tsukagoshi, Analyst, 136, 927-932 (2011).
  • Tube Radial Distribution Phenomenon of Ternary Mixed Solvents in a Microspace under Laminar Flow Conditions: Mari Murakami, Naoya Jinno, Masahiko Hashimoto, Kazuhiko Tsukagoshi, Analytical Sciences, 27, 793-798 (2011).
  • The Micro-Flow Reaction System Featured the Liquid-Liquid Interface Created with Ternary Mixed Carrier Solvents in a Capillary Tube: Yuji Masuhara, Naoya Jinno, Masahiko Hashimoto, and Kazuhiko Tsukagoshi, Analytical Sciences, 28, 439-444 (2012).
  • Study of Outer Phases in Capillary Chromatography, Based on Tube Radial Distribution of Carrier Solvents under Laminar Flow Conditions: Naoya Jinno, Mari Murakami, Kiyoshi Mizohata, Masahiko Hashimoto, and Kazuhiko Tsukagoshi, Journal of Liquid Chromatography & Related Technologies, 35, 1750–1766 (2012).
  • Fundamental Research and Application of the Specific Fluidic Behavior of Mixed Solvents in a Microspace (Invited Review): Kazuhiko Tsukagoshi, Analytical Sciences, 30, 65-73 (2014).
  • Investigation of Specific Microfluidic Flow with Two-phase Separation Mixed Solvent Solutions and Application to Flow Technology: Kazuhiko Tsukagoshi, Journal of Flow Injection Analysis, 32, 89-95 (2015).
  • Consideration of Inner and Outer Phase Configuration in Tube Radial Distribution Phenomenon Based on Viscous Dissipation in a Microfluidic Flow Using Various Types of Mixed Solvent Solutions: Satoshi Fujinaga, Masahiko Hashimoto, Kazuhiko Tsukagoshi, and Jiro Mizushima, Analytical Sciences, 32, 455-461 (2016).
  • Consideration of Tube Radial Distribution Phenomenon under Laminar Flow Conditions Based on the Weber Number: Satoshi Fujinaga, Masahiko Hashimoto, Kazuhiko Tsukagoshi, and Jiro Mizushima, Journal of Chemical Engineering of Japan, 48, 947-952 (2015).
  • Investigation of Tube Radial Distribution Phenomenon (TRDP) and Its Function Appearance: Kazuhiko Tsukagoshi, Kimura Keibun-Sha, Chapters 1-14, pp. 1-372,September, 2015.
  • Tube Radial Distribution Chromatography System Developed by Combining Commercially Available HPLC System and Open-Tubular Capillary Tube as Separation Column: Kento Yamada, Hyo Kan, and Kazuhiko Tsukagoshi, Talanta, 183, 89-93 (2018).
  • Phase-Separation Multiphase Flow: Preliminary Application to Analytical Chemistry; Kazuhiko Tsukagoshi, Analytical Sciences, 40, 9-28 (2024).
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