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Kodera and Hitomi Research Group

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RESEARCH OUTLINE

Research Contents

  • We aim to deepen a chemical understanding of life processes through the synthesis of artificial molecules that can mimic the masterfully designed reactions that take place within living organisms, and based on this knowledge, we work on the development of functional molecules (catalysts, sensors, etc.) of use to humankind. This approach may be called biomimetics or bio-inspired, and it is expected to become a more and more important approach. At this laboratory, we are dedicated to developing a group of useful substances by focusing specifically on biological reactions involving metal ions, synthesising artificial molecules that can mimic these in vivo reactions in order to understand life processes at the molecular level. We are also trying to introduce artificial molecules (designed based on an understanding of in vivo reactions) into living cells to examine the chemical reactions within living organisms.

Research Topics

Development and reaction analysis of enzyme functional model complexes using dinucleating ligands
Development of spontaneous construction methods for multinuclear metal complexes displaying enzyme function
Development of enzyme functional model complexes that function in water
Development of oxidative-stress-sensing probes
Development of bio-compatible multifunctional nanoparticles

Keywords

Dioxygen complex
Oxidation reaction
Enzyme functional model complex
Bio-inspired metal complex
Reactive oxygen species
Oxidative stress
Homeostasis
Fluorescent probes
Bio-imaging
Chemical biology
Bioinorganic chemistry

バナースペース

Department of Applied Chemistry, Graduate School of Science and Engineering
Doshisha University

1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan